| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Marine Exopolysaccharide Complexed with Scandium Aimed as Theranostic Agents
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| Autores: |
Mazza, Mattia
Alliot, Cyrille
Sinquin, Corinne
Colliec-jouault, Sylvia
Reiller, Pascal E.
Huclier-markai, Sandrine
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| Data: |
2021-02
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| Ano: |
2021
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| Palavras-chave: |
Exopolysaccharides
Scandium
Theranostic
Characterization
Complexation
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| Resumo: |
Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. (3) Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. (4) Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00681/79332/81844.pdf
DOI:10.3390/molecules26041143
https://archimer.ifremer.fr/doc/00681/79332/
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| Editor: |
MDPI AG
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| Formato: |
application/pdf
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| Fonte: |
Molecules (1420-3049) (MDPI AG), 2021-02 , Vol. 26 , N. 4 , P. 1143 (23p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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